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Watch Intently (1)pentobarbital will lessen the level or outcome of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. For sufferers obtaining exemestane by using a powerful CYP3A4 inducer the proposed dose of exemestane is fifty mg day-to-day after a food.pentobarbital increases toxicity of ifosfamide b